Milesi began his career by studying cello, composition, and experimental electronic music. He joined the International Folk Group of Moni Ovadia in 1977 as a performer and composer. The composition Modi was created between 1978 and 1980. It is a two part composition which was published in 1982 by the British independent label Cherry Red Records. Since 1984 his compositions have been produced by Studio Azzurro di Milano. The compositions The Nuclear Observatory of Mr. Nanof and Camera astratta (Abstract Chamber) are two soundtracks produced by the American independent label Cuneiform Records. From 1995 to 1996 he arranged, performed and produced Anime salve, the last work of Fabrizio De André, having already orchestrated and arranged Clouds by De André on which Milesi is uncredited. Milesi has composed various soundtracks for film and theater and has worked as an arranger and composer for various Italian pop artists (e.g., Fiorella Mannoia, Luciano Ligabue). Holding a degree in architecture, he has created sound installations and musical interventions in large spaces.